Seminars

The St Andrews Mathematical Biology group runs a seminar series, with talks occurring on Mondays at 1pm. Talks are in person, in Maths Tutorial Room 1A unless otherwise specified.

Upcoming Seminars:

• 07/04/2024 – Dumitru Trucu (University of Dundee) – Maths LT A

  Details to follow

• 17/02/2024 – Philip Murray (University of Dundee) – Maths LT A

  Details to follow

• 03/02/2024 – Cicely Macnamara (University St Andrews) – Maths LT A

  Modelling the tumour microenvironment from individual-based model to PhysiMeSS

  My research has explored various facets of cancer modelling, with my current focus on modelling the tumour microenvironment. Specifically, I have concentrated on understanding the interactions between cancer cells and the extracellular matrix (ECM). The ECM is a complex network of macromolecules, including collagen fibres, that provide structural support to surrounding cells. In the context of cancer metastasis, the ECM acts as a significant barrier, which migrating tumour cells must degrade in order to escape the primary site and invade surrounding tissues. To investigate these processes, I have developed a 3D individual-based model that simulates the behaviour and spatio-temporal interactions of cells, ECM and other tumour microenvironment components. In collaboration with a network of researchers, I have also translated this work into an add-on for PhysiCell, known as PhysiMeSS.

  In this talk, I will present my agent-based model of the tumour microenvironment, while also touching on some of my other related research projects. Additionally, I will take this opportunity to discuss my career trajectory, offering insights into my non-linear path which may be of particular interest to early-career researchers in the group.